RNA Details
Disease Name
liver cirrhosis
Tissue
liver
RNA Symbol
mir-31
RNA ID
RNA Type
miRNA
Alteration Pattern
up regulation
Species
homo sapiens
Detection Methods
PCR; dual-lucimmunofluorescenceerase reporter assay etc.
Target
MIR-31; FIH1; TGF-B
Pathway
TGF-BETA SIGNALING PATHWAY
PubMed ID
Title
The role of the miR-31/FIH1 pathway in TGF-B-induced liver fibrosis
Year
2015
Function
"Tgf-beta downstream transcription factor smad3 stimulates the transcription activity of mir-31 by direct mir-31 promoter, mir-31 mediates fibrosis by targeting fih1, an inhibitor of hypoxia-inducible factor (hif-1) , overexpression significantly promoted hsc activation."